Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells.
Identifieur interne : 004631 ( Main/Exploration ); précédent : 004630; suivant : 004632Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells.
Auteurs : Thedi Ziegler [Finlande] ; Sampsa Matikainen ; Esa Rönkkö ; Pamela Osterlund ; Maarit Sillanp ; Jukka Sirén ; Riku Fagerlund ; Milla Immonen ; Krister Melén ; Ilkka JulkunenSource :
- Journal of virology [ 0022-538X ] ; 2005.
Descripteurs français
- KwdFr :
- ARN messager (analyse), ARN viral (analyse), Animaux, Cellules dendritiques (immunologie), Cellules dendritiques (virologie), Cytokines (génétique), Expression des gènes, Humains, Immunité innée, Lignée cellulaire, Protéines virales (génétique), Protéines virales (métabolisme), Technique de Northern, Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- analyse : ARN messager, ARN viral.
- génétique : Cytokines, Protéines virales, Virus du SRAS.
- immunologie : Cellules dendritiques, Virus du SRAS.
- métabolisme : Protéines virales.
- virologie : Cellules dendritiques.
- Animaux, Expression des gènes, Humains, Immunité innée, Lignée cellulaire, Technique de Northern.
English descriptors
- KwdEn :
- Animals, Blotting, Northern, Cell Line, Cytokines (genetics), Dendritic Cells (immunology), Dendritic Cells (virology), Gene Expression, Humans, Immunity, Innate, RNA, Messenger (analysis), RNA, Viral (analysis), SARS Virus (genetics), SARS Virus (immunology), Viral Proteins (genetics), Viral Proteins (metabolism).
- MESH :
- chemical , analysis : RNA, Messenger, RNA, Viral.
- chemical , genetics : Cytokines, Viral Proteins.
- genetics : SARS Virus.
- immunology : Dendritic Cells, SARS Virus.
- chemical , metabolism : Viral Proteins.
- virology : Dendritic Cells.
- Animals, Blotting, Northern, Cell Line, Gene Expression, Humans, Immunity, Innate.
Abstract
Activation of host innate immune responses was studied in severe acute respiratory syndrome coronavirus (SCV)-infected human A549 lung epithelial cells, macrophages, and dendritic cells (DCs). In all cell types, SCV-specific subgenomic mRNAs were seen, whereas no expression of SCV proteins was found. No induction of cytokine genes (alpha interferon [IFN-alpha], IFN-beta, interleukin-28A/B [IL-28A/B], IL-29, tumor necrosis factor alpha, CCL5, or CXCL10) or IFN-alpha/beta-induced MxA gene was seen in SCV-infected A549 cells, macrophages, or DCs. SCV also failed to induce DC maturation (CD86 expression) or enhance major histocompatibility complex class II expression. Our data strongly suggest that SCV fails to activate host cell cytokine gene expression in human macrophages and DCs.
DOI: 10.1128/JVI.79.21.13800-13805.2005
PubMed: 16227300
Affiliations:
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Le document en format XML
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In all cell types, SCV-specific subgenomic mRNAs were seen, whereas no expression of SCV proteins was found. No induction of cytokine genes (alpha interferon [IFN-alpha], IFN-beta, interleukin-28A/B [IL-28A/B], IL-29, tumor necrosis factor alpha, CCL5, or CXCL10) or IFN-alpha/beta-induced MxA gene was seen in SCV-infected A549 cells, macrophages, or DCs. SCV also failed to induce DC maturation (CD86 expression) or enhance major histocompatibility complex class II expression. Our data strongly suggest that SCV fails to activate host cell cytokine gene expression in human macrophages and DCs.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="Fagerlund, Riku" sort="Fagerlund, Riku" uniqKey="Fagerlund R" first="Riku" last="Fagerlund">Riku Fagerlund</name><name sortKey="Immonen, Milla" sort="Immonen, Milla" uniqKey="Immonen M" first="Milla" last="Immonen">Milla Immonen</name><name sortKey="Julkunen, Ilkka" sort="Julkunen, Ilkka" uniqKey="Julkunen I" first="Ilkka" last="Julkunen">Ilkka Julkunen</name><name sortKey="Matikainen, Sampsa" sort="Matikainen, Sampsa" uniqKey="Matikainen S" first="Sampsa" last="Matikainen">Sampsa Matikainen</name><name sortKey="Melen, Krister" sort="Melen, Krister" uniqKey="Melen K" first="Krister" last="Melén">Krister Melén</name><name sortKey="Osterlund, Pamela" sort="Osterlund, Pamela" uniqKey="Osterlund P" first="Pamela" last="Osterlund">Pamela Osterlund</name><name sortKey="Ronkko, Esa" sort="Ronkko, Esa" uniqKey="Ronkko E" first="Esa" last="Rönkkö">Esa Rönkkö</name><name sortKey="Sillanp, Maarit" sort="Sillanp, Maarit" uniqKey="Sillanp M" first="Maarit" last="Sillanp">Maarit Sillanp</name><name sortKey="Siren, Jukka" sort="Siren, Jukka" uniqKey="Siren J" first="Jukka" last="Sirén">Jukka Sirén</name></noCountry><country name="Finlande"><noRegion><name sortKey="Ziegler, Thedi" sort="Ziegler, Thedi" uniqKey="Ziegler T" first="Thedi" last="Ziegler">Thedi Ziegler</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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